Frequently Asked Questions
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Semaglutide and Tirzepatide, medications commonly used to treat type 2 diabetes and for weight management, have gained considerable attention recently. Here are some frequently asked questions (FAQs):
What is semaglutide and tirzepatide, and how do they work?
Semaglutide is the active ingredient found in name-brand medications like Ozempic®. Semaglutide is a glucagon-like-peptide-1 receptor agonist prescribed as an additional weight loss support to a healthy diet and exercise regimen for weight loss and weight management.
In June of 2021, the FDA approved semaglutide for weight loss.
Semaglutide acts like GLP-1 (a gut hormone) to increase insulin production, decrease glucagon synthesis, and suppress hunger. It sends a signal to your brain that you are full, so you can lose weight without feeling like you are starving yourself.
While Tirzepatide and semaglutide both decrease the feelings of hunger, Tirzepatide is also a GIP receptor. GIP is a hormone produced by the small intestine that increases insulin release after eating food.
Is semaglutide or tirzepatide right for me?
Semaglutide is marketed under other brand names like Ozempic and Wegovy.
Tirzepatide is marketed under brand names like Zepbound.
What brand names are Semaglutide and Tirzepatide sold under?
Semaglutide is marketed under other brand names like Ozempic and Wegovy.
Tirzepatide is marketed under brand names like Zepbound.
Can I lose weight with semaglutide/tirzepatide?
Every person’s body responds differently to medications. There have been various studies conducted, and on average, over a year and a half period, participants in the study lost an average of 15% of their body weight, and 1/3 of participants lost over 20% of their body weight.
Am I a good candidate for semaglutide or tirzepatide?
If you want to lose weight, have a BMI of 27 or higher, hypertension, Type 2 Diabetes, or hyperlipidemia, you may be a great candidate.
Do you have further questions? Consult with our physician!
Who is NOT a good candidate for semaglutide or tirzepatide?
If you:
- Are pregnant or breastfeeding (unless specifically advised by a doctor)
- Have Type 1 Diabetes Mellitus
- Have a hypersensitivity to semaglutide or any of its components
- Have personal or family history of medullary thyroid carcinoma (MTC)
- Have a history of multiple endocrine neoplasia syndrome (MEN 2)
- Have a history of pancreatitis
- Are in the end stage renal disease (on dialysis)
- Have a BMI <25
- Have Type 2 Diabetes and are on insulin or a sulfonylurea
- Have diabetic retinopathy
- Are on several antihypertensive medications.
- For tirzepatide, you are not an adult.
- For semaglutide, you are under 12 years old.
When and where should I administer semaglutide or tirzepatide?
It can be administered weekly, at any time of day, but on the same day every week.
It should be injected subcutaneously into your upper arm, abdomen, or your thigh.
Are there any side effects?
Although there are rarely any side effects reported, with any medication, there might be some. Everyone’s experience is different. While rare, the most common side effects include nausea, diarrhea or constipation, a bloated feeling or an upset stomach, heartburn, dizziness, fatigue, headaches, or vomiting.
How long should I take semaglutide or tirzepatide? Is it safe for long-term use?
This depends on the amount of weight you desire to lose, and should be discussed with our physician on an ongoing basis in your follow ups.
Long-term studies are ongoing, but current data suggest that semaglutide and tirzepatide are generally safe when used as directed. Regular follow-ups with your healthcare provider are important to monitor any potential side effects or complications.
Can I eat what I want?
While we recommend sticking to a healthy diet for a lifestyle of wellness, not just temporarily for weight loss, there are no specific restrictions on what you can eat.
Can I exercise while on semaglutide or tirzepatide?
Yes. There are no exercise restrictions.
Can semaglutide or tirzepatide cause low blood sugar (hypoglycemia)?
Semaglutide or tirzepatide alone is unlikely to cause hypoglycemia. However, when combined with other diabetes medications like insulin or sulfonylureas, the risk increases. Monitoring blood sugar levels is important.
How effective is semaglutide or tirzepatide for weight loss?
Clinical trials have shown that semaglutide and tirzepatide can lead to significant weight loss. In some studies, participants lost up to 15-20% of their body weight over 68 weeks when combined with lifestyle modifications.
What should I tell my doctor before starting semaglutide or tirzepatide?
Inform your doctor about:
- Any medical history, particularly related to thyroid issues, pancreas problems, kidney disease, or gastrointestinal issues.
- All medications, supplements, and herbs you’re currently taking.
- Any history of alcohol use.
- If you’re pregnant, planning to become pregnant, or breastfeeding.
How long does it take for semaglutide or tirzepatide to start working?
For weight loss, effects may become noticeable after several weeks to months, depending on the individual.
Can I stop taking semaglutide or tirzepatide abruptly?
It’s not recommended to stop taking semaglutide or tirzepatide without consulting your healthcare provider. Abruptly stopping can lead to a return of high blood sugar levels in diabetics or weight regain in those using it for weight management.
Does semaglutide or tirzepatide interact with other medications?
Semaglutide and tirzepatide may interact with other medications, particularly those that affect blood sugar levels. It’s important to discuss all medications you’re taking with your healthcare provider.
Always consult with a healthcare professional before making any decisions related to the use of Semaglutide.
What is the difference between semaglutide and tirzepatide?
Semaglutide works solely as a GLP-1 receptor agonist in the brain, causing a lesser feeling of hunger and reduced cravings for food. Tirzepatide combines the actions of GLP-1 and GIP receptor agonists, providing a greater reduction in appetite than semaglutide by itself.
